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KMID : 0614620070490020072
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Korean Journal of Gastroenterology
2007 Volume.49 No. 2 p.72 ~ p.78
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Expression of Peroxisome Proliferator-activated Receptor (PPAR) γ in Helicobacter pylori-infected Gastric Epithelium
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Son Seong-Hyun
Kim Hyung-Keun
Ji Jeong-Seon
Kim Sung-Soo
Chae Hiun-Suk
Choi Myung-Gyu
Han Sok-Won
Choi Gyu-Yong
Chung In-Sik
Shin Ok-Ran
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Abstract
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Background/Aims: Peroxisome proliferator-activated receptor γ (PPARγ), a nuclear transcription factor, plays a critical role in the regulation of gene expression associated with inflammation and cancer. PPAR γ is expressed in human gastric cancer as well as in colon cancer. Activation of PPAR γ by ligand produces pro-apoptotic effect and ameliorate growing of cancer cells. Helicobacter pylori (H. pylori) is a main etiologic agent for gastric inflammation, and raises cell turnover in gastric epithelium. Longstanding infection with this organism is related with the development of non-cardiac gastric cancer. The aim of this study was to investigate the effect of H. pylori on the expression of PPARγ protein and mRNA in chronic gastritis.
Methods: Gastric biopsy samples were taken from H. pylori infected (n=18) and non-infected (n=21) patients during endoscopic examination. PPAR γ expressions were assessed by real time polymerase chain reaction and immunohistochemistry.
Results: PPAR γ was localized to the nuclei of the foveolar epithelial cells in both infected and non-infected mucosa. PPAR γ protein expression was higher in H. pylori infected patients than in non-infected patients (3.8±0.4 vs. 2.6±1.0, H. pylori infected and non-infected, respectively; p＜0.05). However, PPAR γ mRNA levels were not significantly different between the two groups (24±18 vs. 29±25, H. pylori infected and noninfected, respectively).
Conclusion: PPAR γ expression is increased in the gastric mucosa of H. pylori infected chronic gastritis, which suggests a certain role of PPARγ in the mucosal inflammatory reaction to H. pylori infection. (Korean J Gastroenterol 2007;49:72-78)
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KEYWORD
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Helicobacter pylori, Peroxisome proliferator-activated receptor γ
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